Nuclear Magnetic Resonance : NMR

Principle

NMR spectra are obtained using the phenomenon of nuclear magnetic resonance. By elucidating the NMR spectra, the information about the 1H and 13C (and sometimes other nuclei) in organic compounds can be obtained. The chemical shifts provide information on the type of nucleus (aliphatic, aromatic, etc.), the peak integrals provide information on the number of nuclei, and the couplings (spin bonds) provide information on the neighboring nuclei.
In 2D NMR, the spectra are expanded into two dimensions by devising a pulse sequence to more directly extract information on spin coupling, etc. This makes it possible to analyze compounds with complex structures, such as pharmaceuticals and functional dyes.