Liquid Chromatography - Nuclear Magnetic Resonance

Principle

LC-NMR, as the name implies, is a directly combined system of HPLC and NMR. Its main features are high sensitivity and reduced separation steps, which make it a powerful tool for structural analysis of trace components (impurities, degradation products, metabolites, etc.) and unstable substances that are easily damaged by separation and purification. In particular, when it is necessary to identify the structural differences between isomers, decisive information for defining the structures can be obtained. Thus, combined use of LC-NMR with LC/MS and LC/MS/MS in the structural analysis of trace components and unstable substances enables researchers to obtain useful structural information without isolating the trace components.