Isothermal Titration Calorimetry

Principle

A method to detect the heat of reaction (ΔH) associated with molecular interaction.

・Affinity (Ka), stoichiometry (n), enthalpy change (ΔH), and entropy change (ΔS) can be obtained.

・Intermolecular binding modes (specific or non-specific) can be predicated from obtained thermodynamic profiles.