- Structural Analysis of Nucleic Acids by CD and NMR
Higher-order structure of nucleic acids varies depending on the base sequence, salt concentration and temperature.
CD (circular dichroism) and NMR (nuclear magnetic resonance) are commonly used for the evaluation of higher-order structure of nucleic acids. The following are examples of structural analysis of nucleic acids using the CD and NMR.
- Structural analysis of peptide trace decompositions
Peptides, middle-size molecules, are big hope as one of next-generation drugs. The structural analysis of the decomposition and impurities is critical to ensuring stable quality. TRC possesses technologies for small molecule drugs, ranging from fractionation and structural analysis of trace components of APIs and drug products, and peptide synthesis technologies. Here is an example of our structural analysis of Ghrelin(1-8) trace decomposition using MS and NMR.
- Analytical Technics for benchmark of in vitro diagnostics
Recently, initial cancer diagnosis and pre-symptomatic diagnosis are regarded as important for extension of healthy life expectancy. Our analysis technics is available for several points such as inorganic, organic analysis and interaction analysis of antigen‐antibody reaction for in vitro diagnostics.
- Analytical evaluation of biosensors
Biosensors utilize the fact that chemical substances derived from living organisms, such as enzymes and antibodies, react only with specific substances. Its technology is expected to be applied to a wide range of fields. TRC provides biosensor composition package analysis such as deterioration, durability, storage stability, and evaluation of materials.